https://lunacysaint.github.io/tags/vegf/ VEGF Hugo Blox Builder (https://hugoblox.com)en-usThu, 22 Oct 2026 17:30:00 +0000 https://lunacysaint.github.io/media/icon_hu15511076651403545720.png https://lunacysaint.github.io/tags/vegf/ https://lunacysaint.github.io/event/2026_10_22_journal-meeting/ Thu, 22 Oct 2026 17:30:00 +0000 https://lunacysaint.github.io/event/2026_10_22_journal-meeting/ <h2 id="presentation-highlights--報告精華">Presentation Highlights / 報告精華</h2> <p><strong>Introduction &amp; Rationale</strong></p> <p>Cognitive decline progresses more rapidly in women than in men, with a higher prevalence of neurodegenerative diseases observed in females. While exercise has been shown to enhance cognitive function through the upregulation of neurotrophic factors (like BDNF, VEGF, and IGF-1), high-load resistance exercise may not be suitable for all populations, particularly middle-aged women. Low-load resistance exercise with blood flow restriction (LLBFR) has emerged as an effective alternative.</p> <p><strong>Key Findings</strong></p> <ul> <li><strong>Cognitive Performance</strong>: Only the LLBFR condition showed significant improvements in Color-Word Stroop Task (CWST) reaction time, with no changes in error rates, indicating enhanced cognitive performance.</li> <li><strong>Neurotrophic Factors</strong>: Serum BDNF and VEGF levels increased significantly following both LLBFR and moderate-load resistance exercise (MLRE). IGF-1 levels remained unchanged across conditions.</li> <li><strong>Metabolic Responses</strong>: Increases in lactate concentrations were positively correlated with changes in BDNF and VEGF.</li> </ul> <p><strong>Practical Application</strong></p> <p>A single session of LLBFR successfully improves cognitive function and upregulates key neurotrophic factors (BDNF and VEGF) in middle-aged women. This makes LLBFR an effective and practical intervention for promoting cognitive health in this population.</p> <hr> <p><strong>研究動機與背景</strong></p> <p>女性認知衰退的速度較男性更快，且神經退化性疾病的盛行率也較高。雖然運動能透過提升神經營養因子（如 BDNF、VEGF 和 IGF-1）來改善認知功能，但高負荷阻力訓練並不一定適合所有族群，尤其是中年女性。因此，低負荷血流限制阻力訓練（LLBFR）成為了一種安全且有效的替代方案。</p> <p><strong>核心發現</strong></p> <ul> <li><strong>認知表現</strong>：僅有 LLBFR 組在史楚普色詞測驗（CWST）的反應時間有顯著進步，且錯誤率未增加，顯示認知表現獲得實質提升。</li> <li><strong>神經營養因子</strong>：在執行 LLBFR 與中等負荷阻力訓練（MLRE）後，血清中的 BDNF 與 VEGF 濃度皆顯著上升，而 IGF-1 則無顯著變化。</li> <li><strong>代謝反應</strong>：乳酸濃度的增加與 BDNF 及 VEGF 的變化量呈現正相關。</li> </ul> <p><strong>實務建議</strong></p> <p>單次低負荷血流限制阻力訓練（LLBFR）即可改善中年女性的認知功能，並提升關鍵的神經營養因子（BDNF 與 VEGF）。這項結果表明，LLBFR 可作為促進該族群認知健康的有效介入策略。</p> <hr> <h3 id="報告資訊">報告資訊</h3> <ul> <li><strong>Presenter / 報告人</strong>: Steve Ying-Chu Chen, Ph.D. candidate</li> <li><strong>Advisor / 指導教授</strong>: Yu-Kai Chang (張育愷), Ph.D.</li> <li><strong>Lab / 實驗室</strong>: Physical Activity &amp; Cognitive Neuroscience Lab (PACN Lab), NTNU</li> </ul>